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Clinical Guideline Development (Part 4): From Search Strategy to Submission – What a Credible Guideline Methods Section Actually Looks Like

  In 2025, a systematic review assessed the methodological rigour of 76 clinical practice guidelines published by the European Society of Cardiology (ESC) and the...

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Clinical Guideline Development (Part 3): Delphi, Nominal Group, or RAND/UCLA? Choosing the Right Consensus Method for Your Guideline

  In 1951, the United States Air Force had a question that could not be answered by experiment: how many atomic bombs would be required...

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Clinical Guideline Development Part 2: GRADE, AGREE, and the Alphabet Soup of Evidence Appraisal

  In 1990, while serving as director of the internal medicine residency program at McMaster University in Hamilton, Ontario, Gordon Guyatt introduced a new approach...

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From Hippocrates to Delphi: A Practical Guide to Clinical Guideline Development Part 1: Not All Guidance Is Created Equal

This is the first in a five-part series on the science and methodology behind clinical practice guidelines and consensus statements. The series “From Hippocrates to...

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FDA Just Issued Its First AI Warning Letter: Medical Affairs Should Pay Attention

On April 2, 2026, the U.S. Food and Drug Administration issued a warning letter to a Michigan-based manufacturer of drug products called Purolea Cosmetics Lab....

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