June 16, 2026
Many guideline failures are not failures of evidence alone, they are failures of process. Economic constraints, logistical complexity, and political realities exert a profound...
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June 9, 2026
In 2025, a systematic review assessed the methodological rigour of 76 clinical practice guidelines published by the European Society of Cardiology (ESC) and the...
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June 2, 2026
In 1951, the United States Air Force had a question that could not be answered by experiment: how many atomic bombs would be required...
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May 26, 2026
In 1990, while serving as director of the internal medicine residency program at McMaster University in Hamilton, Ontario, Gordon Guyatt introduced a new approach...
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May 20, 2026
This is the first in a five-part series on the science and methodology behind clinical practice guidelines and consensus statements. The series “From Hippocrates to...
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